A Model for Transposition of the Colistin Resistance Gene mcr-1 by IS Apl1 | Zendy

Erik Snesrud | Zendy; Susu He | Zendy; Michaël Chandler | Zendy; John P. Dekker | Zendy; Alison B. Hickman | Zendy; Patrick McGann | Zendy; Fred Dyda | Zendy

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A Model for Transposition of the Colistin Resistance Gene mcr-1 by IS Apl1

Author(s) -

Erik Snesrud,

Susu He,

Michaël Chandler,

John P. Dekker,

Alison B. Hickman,

Patrick McGann,

Fred Dyda

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01457-16

Subject(s) - mcr 1 , transposition (logic) , colistin , genetics , gene , biology , microbiology and biotechnology , antibiotics , enterobacteriaceae , mathematics , escherichia coli , geometry

Analysis ofmcr-1 -containing sequences identified a common ∼2,607-bp DNA segment that in many cases is flanked on one or both ends by ISApl1 . We present evidence thatmcr-1 is mobilized by an ISApl1 composite transposon which has, in some cases, subsequently lost one or both copies of ISApl1 . We also show thatmcr-1 can be mobilized in some circumstances by a single upstream copy of ISApl1 in conjunction with the remnants of a downstream ISApl1 .

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