Clonal Spread of mef -Positive Macrolide-Resistant Streptococcus pneumoniae Isolates Causing Invasive Disease in Adults in Germany | Zendy

Mark van der Linden | Zendy; Adnan AlLahham | Zendy; Stefan Haupts | Zendy; Ralf René Reinert | Zendy

Open Access

Clonal Spread of mef -Positive Macrolide-Resistant Streptococcus pneumoniae Isolates Causing Invasive Disease in Adults in Germany

Author(s) -

Mark van der Linden,

Adnan AlLahham,

Stefan Haupts,

Ralf René Reinert

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01453-06

Subject(s) - streptococcus pneumoniae , serotype , genotype , biology , microbiology and biotechnology , multilocus sequence typing , erythromycin , clone (java method) , virology , drug resistance , antibiotics , genetics , gene

Isolates (3,845) obtained from German adults with invasive pneumococcal disease between 1992 and 2004 were investigated. Of these, 430 isolates (11.2%) were erythromycin A nonsusceptible. Macrolide resistance genotypes and multilocus sequence types were determined. Among the isolates, 35.6% were erm(B) positive and 63.5% were mef positive. Over the study period, the frequency of resistance rose significantly from 2.2 to 17.0% (P < 0.001). A serotype 14, sequence type 9 clone was the most widespread.

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