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AnEnterobacter ludwigii strain was isolated during routine screening of a Japanese patient for carriage of carbapenem-resistantEnterobacteriaceae . PCR analysis revealed thebla NMC-A carbapenemase gene. Whole-genome sequencing revealed thatbla NMC-A was inserted in the chromosome and associated with a novel 29.1-kb putative Xer-dependent integrative mobile element, named EludIMEX-1. Bioinformatic analysis identified similar elements in the genomes of anEnterobacter asburiae strain and of otherEnterobacter cloacae complex strains, confirming the mobile nature of this element.

antimicrobial agents and chemotherapy

Characterization of a Novel Putative Xer-Dependent Integrative Mobile Element Carrying the <i>bla</i> <sub>NMC-A</sub> Carbapenemase Gene, Inserted into the Chromosome of Members of the Enterobacter cloacae Complex

Characterization of a Novel Putative Xer-Dependent Integrative Mobile Element Carrying the bla NMC-A Carbapenemase Gene, Inserted into the Chromosome of Members of the Enterobacter cloacae Complex

Characterization of a Novel Putative Xer-Dependent Integrative Mobile Element Carrying the bla _NMC-A Carbapenemase Gene, Inserted into the Chromosome of Members of the Enterobacter cloacae Complex