Anidulafungin and Micafungin MIC Breakpoints Are Superior to That of Caspofungin for Identifying FKS Mutant Candida glabrata Strains and Echinocandin Resistance | Zendy

Ryan K. Shields | Zendy; M. Hong Nguyen | Zendy; Ellen G. Press | Zendy; Cassaundra L. Updike | Zendy; Cornelius J. Clancy | Zendy

Open Access

Anidulafungin and Micafungin MIC Breakpoints Are Superior to That of Caspofungin for Identifying FKS Mutant Candida glabrata Strains and Echinocandin Resistance

Author(s) -

Ryan K. Shields,

M. Hong Nguyen,

Ellen G. Press,

Cassaundra L. Updike,

Cornelius J. Clancy

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01451-13

Subject(s) - anidulafungin , echinocandin , micafungin , caspofungin , echinocandins , candida glabrata , context (archaeology) , microbiology and biotechnology , biology , pharmacology , medicine , antifungal , fluconazole , paleontology

By CLSI interpretive criteria, anidulafungin and micafungin MICs determined by various methods were sensitive (60 to 70%) and highly specific (94 to 100%) for identifying FKS mutations among 120 Candida glabrata isolates. Anidulafungin and micafungin breakpoints were more specific than CLSI's caspofungin breakpoint in identifying FKS mutant strains and patients with invasive candidiasis who were likely to fail echinocandin treatment (P ≤ 0.0001 for both). Echinocandin MICs were most useful clinically when interpreted in the context of prior echinocandin exposure.

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