Distribution of Hydroxychloroquine in Lymphoid Tissue in a Rabbit Model for HIV Infection | Zendy

Iliana GonzálezHernández | Zendy; Lucinda AguirreCruz | Zendy; Julio Sotelo | Zendy; Raquel LópezArellano | Zendy; Adriana Morales-Hipólito | Zendy; Helgi Jung–Cook | Zendy

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Distribution of Hydroxychloroquine in Lymphoid Tissue in a Rabbit Model for HIV Infection

Author(s) -

Iliana GonzálezHernández,

Lucinda AguirreCruz,

Julio Sotelo,

Raquel LópezArellano,

Adriana Morales-Hipólito,

Helgi Jung–Cook

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01440-13

Subject(s) - lymphatic system , hydroxychloroquine , lymph , spleen , pathology , distribution (mathematics) , human immunodeficiency virus (hiv) , medicine , tissue distribution , immunology , biology , infectious disease (medical specialty) , mathematical analysis , mathematics , disease , covid-19

Hydroxychloroquine has been proposed for HIV treatment; however, little is known about its disposition in the lymphatic system, where replication takes place. Therefore, its distribution in lymphoid tissues (Peyer's patches and popliteal, submandibular, femoral, splenic, and prescapular lymph nodes) was evaluated and compared with that in blood. Results showed a high affinity of hydroxychloroquine for all of these tissues, with higher affinity for the splenic and submandibular lymph nodes, suggesting its potential use as a coadjuvant in HIV therapy.

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