Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in a Murine Model of Pyelonephritis | Zendy

Jason Weiss | Zendy; Mark Pulse | Zendy; Phung M. Nguyen | Zendy; Kelly Peterson | Zendy; Jessica Silva-Fisher | Zendy; Jerry W. Simecka | Zendy; David Valtierra | Zendy; Mojgan Sabet | Zendy; David C. Griffith | Zendy

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Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in a Murine Model of Pyelonephritis

Author(s) -

Jason Weiss,

Mark Pulse,

Phung M. Nguyen,

Kelly Peterson,

Jessica Silva-Fisher,

Jerry W. Simecka,

David Valtierra,

Mojgan Sabet,

David C. Griffith

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01439-17

Subject(s) - enterobacteriaceae , meropenem , klebsiella pneumoniae , carbapenem resistant enterobacteriaceae , carbapenem , microbiology and biotechnology , medicine , antibiotics , ceftazidime/avibactam , biology , escherichia coli , antibiotic resistance , gene , biochemistry

The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especiallyKlebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistantEnterobacteriaceae . We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolates in a murine pyelonephritis model. The data indicate that the combination of meropenem and vaborbactam significantly increased bacterial killing compared to that with the untreated controls. These data suggest that this combination may have utility in the treatment of complicated urinary tract infections due to KPC-producing, carbapenem-resistantEnterobacteriaceae .

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