Fluoroquinolone Resistance in Haemophilus influenzae Is Associated with Hypermutability | Zendy

Marı́a Pérez-Vázquez | Zendy; Federico Román | Zendy; Silvia García-Cobos | Zendy; José Campos | Zendy

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Fluoroquinolone Resistance in Haemophilus influenzae Is Associated with Hypermutability

Author(s) -

Marı́a Pérez-Vázquez,

Federico Román,

Silvia García-Cobos,

José Campos

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01437-06

Subject(s) - haemophilus influenzae , microbiology and biotechnology , porin , ciprofloxacin , haemophilus , biology , efflux , mutant , genetics , bacteria , escherichia coli , antibiotics , gene , bacterial outer membrane

Forty-three percent (12/28) of ciprofloxacin (CIP)-nonsusceptible respiratory isolates of Haemophilus influenzae were hypermutable, compared with 8.5% (3/35) in the CIP-susceptible control group (P=0.002). CIP-nonsusceptible mutants were obtained with hypermutable strains only; these mutants developed three resistance mechanisms in a step-by-step process: target modifications, loss of a porin protein, and increased efflux.

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