MIC Values of Voriconazole Are Predictive of Treatment Results in Murine Infections by Aspergillus terreus Species Complex | Zendy

Valentina Salas | Zendy; Francisco Pastor | Zendy; Deanna A. Sutton | Zendy; Enrique Calvo | Zendy; Emilio Mayayo | Zendy; Annette W. Fothergill | Zendy; Michael G. Rinaldi | Zendy; Josep Guarro | Zendy

Open Access

MIC Values of Voriconazole Are Predictive of Treatment Results in Murine Infections by Aspergillus terreus Species Complex

Author(s) -

Valentina Salas,

Francisco Pastor,

Deanna A. Sutton,

Enrique Calvo,

Emilio Mayayo,

Annette W. Fothergill,

Michael G. Rinaldi,

Josep Guarro

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01436-12

Subject(s) - aspergillus terreus , voriconazole , galactomannan , aspergillus , aspergillosis , microbiology and biotechnology , biology , predictive value , medicine , immunology , antifungal

We evaluated the efficacy of voriconazole against nine strains ofAspergillus terreus with different MICs (0.12 to 4 μg/ml) by using a murine model. Markers of efficacy included survival, tissue burden, galactomannan antigenemia, and drug serum levels. Voriconazole was especially effective in prolonging survival and reducing the fungal load in infections by strains that showed MICs that were less than or equal to the epidemiological cutoff value (1 μg/ml).In vitro data might be useful for predicting the outcome ofA. terreus infections.

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