New Structure of Phage-Related Islands Carrying fusB and a Virulence Gene in Fusidic Acid-Resistant Staphylococcus epidermidis | Zendy

Hsiao-Jan Chen | Zendy; YaChun Chang | Zendy; JuiChang Tsai | Zendy; WeiChun Hung | Zendy; Yu-Tzu Lin | Zendy; Shang-Jie You | Zendy; SungPin Tseng | Zendy; LeeJene Teng | Zendy

Open Access

New Structure of Phage-Related Islands Carrying fusB and a Virulence Gene in Fusidic Acid-Resistant Staphylococcus epidermidis

Author(s) -

Hsiao-Jan Chen,

YaChun Chang,

JuiChang Tsai,

WeiChun Hung,

Yu-Tzu Lin,

Shang-Jie You,

SungPin Tseng,

LeeJene Teng

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01433-13

Subject(s) - fusidic acid , virulence , staphylococcus epidermidis , microbiology and biotechnology , biology , virology , gene , staphylococcus aureus , bacteria , genetics

Nucleotide sequencing of the fusB-flanking regions in two fusidic acid-resistant Staphylococcus epidermidis isolates with the type IV aj1-leader peptide (LP)-fusB structure (lacking aj1) revealed that their fusB gene was located on novel phage-related islands inserted downstream of smpB and are here referred to as SeRIfusB-3692 and SePIfusB-857. The novel SePIfusB-857 structure was followed by SeCI857, forming a composite pathogenicity island which contained a putative virulence gene, vapE. The linkage of fusB and vapE may contribute to bacterial adaption.

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