Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus , Escherichia coli , and Pseudomonas aeruginosa | Zendy

Tetsufumi Koga | Zendy; Chika Sugihara | Zendy; Masayo Kakuta | Zendy; Nobuhisa Masuda | Zendy; Eiko Namba | Zendy; Takashi Fukuoka | Zendy

Open Access

Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus , Escherichia coli , and Pseudomonas aeruginosa

Author(s) -

Tetsufumi Koga,

Chika Sugihara,

Masayo Kakuta,

Nobuhisa Masuda,

Eiko Namba,

Takashi Fukuoka

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01433-08

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , staphylococcus aureus , escherichia coli , penicillin binding proteins , imipenem , biology , penicillin , bacteria , antibiotics , antibiotic resistance , biochemistry , gene , genetics

Tomopenem (formerly CS-023), a novel 1beta-methylcarbapenem, exhibited high affinity for penicillin-binding protein (PBP) 2 in Staphylococcus aureus, PBP 2 in Escherichia coli, and PBPs 2 and 3 in Pseudomonas aeruginosa, which are considered major lethal targets. Morphologically, tomopenem induced spherical forms in E. coli and short filamentation with bulges in P. aeruginosa, which correlated with the drug's PBP profiles. The potential of resistance of these bacteria to tomopenem was comparable to that to imipenem.

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