Emergence of Various NDM-Type-Metallo-β-Lactamase-Producing Escherichia coli Clinical Isolates in Nepal | Zendy

Basudha Shrestha | Zendy; Tatsuya Tada | Zendy; Kayo Shimada | Zendy; Shovita Shrestha | Zendy; Hiroshi Ohara | Zendy; Bharat Mani Pokhrel | Zendy; Jeevan B. Sherchand | Zendy; Teruo Kirikae | Zendy

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Emergence of Various NDM-Type-Metallo-β-Lactamase-Producing Escherichia coli Clinical Isolates in Nepal

Author(s) -

Basudha Shrestha,

Tatsuya Tada,

Kayo Shimada,

Shovita Shrestha,

Hiroshi Ohara,

Bharat Mani Pokhrel,

Jeevan B. Sherchand,

Teruo Kirikae

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01425-17

Subject(s) - meropenem , biology , microbiology and biotechnology , escherichia coli , imipenem , carbapenem , enterobacteriaceae , 16s ribosomal rna , bacteria , antibiotics , gene , genetics , antibiotic resistance

Of 250 clinical isolates of Escherichia coli obtained in Nepal, 38 were carbapenem resistant, with MICs of imipenem or meropenem of ≥4 μg/ml. All 38 isolates harbored the following bla NDM s: bla NDM-1 , bla NDM-3 , bla NDM-4 , bla NDM-5 , bla NDM-7 , bla NDM-12 , and bla NDM-13 Most of these isolates also harbored the 16S rRNA methylase gene(s) armA , rmtB , and/or rmtC .

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