Assessment of Serum (1→3)-β- d -Glucan Concentration as a Measure of Disease Burden in a Murine Model of Invasive Pulmonary Aspergillosis | Zendy

Nathan P. Wiederhold | Zendy; Laura K. Najvar | Zendy; Ana C. Vallor | Zendy; William R. Kirkpatrick | Zendy; Rosie Bocanegra | Zendy; D. Kimberley Molina | Zendy; Marcos Olivo | Zendy; John R. Graybill | Zendy; Thomas F. Patterson | Zendy

Open Access

Assessment of Serum (1→3)-β- d -Glucan Concentration as a Measure of Disease Burden in a Murine Model of Invasive Pulmonary Aspergillosis

Author(s) -

Nathan P. Wiederhold,

Laura K. Najvar,

Ana C. Vallor,

William R. Kirkpatrick,

Rosie Bocanegra,

D. Kimberley Molina,

Marcos Olivo,

John R. Graybill,

Thomas F. Patterson

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01425-07

Subject(s) - glucan , antifungal , aspergillosis , pulmonary aspergillosis , biomarker , microbiology and biotechnology , medicine , immunology , pharmacology , biology , biochemistry

Serum (1→3)-β-d -glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1→3)-β-d -glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.

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