Open AccessAssessment of Serum (1→3)-β- d -Glucan Concentration as a Measure of Disease Burden in a Murine Model of Invasive Pulmonary Aspergillosis
Author(s) -
Nathan P. Wiederhold,
Laura K. Najvar,
Ana C. Vallor,
William R. Kirkpatrick,
Rosie Bocanegra,
D. Kimberley Molina,
Marcos Olivo,
John R. Graybill,
Thomas F. Patterson
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01425-07
Subject(s) - glucan , antifungal , aspergillosis , pulmonary aspergillosis , biomarker , microbiology and biotechnology , medicine , immunology , pharmacology , biology , biochemistry
Serum (1→3)-β-d -glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1→3)-β-d -glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.