Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains | Zendy

Ilya Lebeau | Zendy; Graciela Andreï | Zendy; Marcela Krečmerová | Zendy; Erik De Clercq | Zendy; Antonı́n Holý | Zendy; Robert Snoeck | Zendy

Open Access

Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains

Author(s) -

Ilya Lebeau,

Graciela Andreï,

Marcela Krečmerová,

Erik De Clercq,

Antonı́n Holý,

Robert Snoeck

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01422-06

Subject(s) - simian , virology , primate , biology , virus , nonhuman primate , nucleoside , haplorhini , genetics , neuroscience , evolutionary biology

Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research