Open AccessStructural Insights into Catalytic Relevances of Substrate Poses in ACC-1
Author(s) -
Da-Woon Bae,
Ye-Eun Jung,
Young Jun An,
JungHyun Na,
SunShin Cha
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01411-19
Subject(s) - substrate (aquarium) , catalysis , substrate specificity , computer science , computational biology , chemistry , combinatorial chemistry , biology , biochemistry , ecology , enzyme
ACC-1 is a plasmid-encoded class C β-lactamase identified in clinical isolates ofKlebsiella pneumoniae ,Proteus mirabilis ,Salmonella enterica , andEscherichia coli . ACC-1-producing bacteria are susceptible to cefoxitin, whereas they are resistant to oxyimino cephalosporins. Here, we depict crystal structures of apo ACC-1, adenylylated ACC-1, and acylated ACC-1 complexed with cefotaxime and cefoxitin.
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