Open AccessIn Vitro and In Vivo Antibacterial Activities of DW-224a, a New Fluoronaphthyridone
Author(s) -
Hee-Soo Park,
HyunJoo Kim,
Min-Jung Seol,
Dong-Rack Choi,
EungChil Choi,
JinHwan Kwak
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01407-05
Subject(s) - in vivo , bacteria , in vitro , quinolone , microbiology and biotechnology , antibacterial activity , gram negative bacteria , gram , gram positive bacteria , antibacterial agent , biology , antibiotics , chemistry , escherichia coli , biochemistry , genetics , gene
DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.