Open AccessFirst Identification of Pseudomonas aeruginosa Isolates Producing a KPC-Type Carbapenem-Hydrolyzing β-Lactamase
Author(s) -
María Virginia Villegas,
Karen Lolans,
Adriana Correa,
Juan Nicolás Kattán,
Jaime Alberto López,
John P. Quinn
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01405-06
Subject(s) - citrobacter freundii , imipenem , pseudomonas aeruginosa , microbiology and biotechnology , carbapenem , biology , enterobacteriaceae , beta lactamase , pseudomonadaceae , bacteria , antibiotic resistance , antibiotics , escherichia coli , gene , genetics
In Medellin, Colombia, threePseudomonas aeruginosa isolates with high-level carbapenem resistance (MIC ≥ 256 μg/ml) and an isolate ofCitrobacter freundii with reduced susceptibility to imipenem produced the plasmid-mediated class A carbapenemase KPC-2. This is the first report of a KPC-type β-lactamase identified outside of the familyEnterobacteriaceae .