Restoration of Chloride Efflux by Azithromycin in Airway Epithelial Cells of Cystic Fibrosis Patients | Zendy

Vinciane SaintCriq | Zendy; Carine Rebeyrol | Zendy; Ma Ruffin | Zendy; Telma Roque | Zendy; Loïc Guillot | Zendy; Jacky Jacquot | Zendy; Annick Clément | Zendy; Olivier Tabary | Zendy

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Restoration of Chloride Efflux by Azithromycin in Airway Epithelial Cells of Cystic Fibrosis Patients

Author(s) -

Vinciane SaintCriq,

Carine Rebeyrol,

Ma Ruffin,

Telma Roque,

Loïc Guillot,

Jacky Jacquot,

Annick Clément,

Olivier Tabary

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01403-10

Subject(s) - azithromycin , cystic fibrosis , efflux , airway , medicine , respiratory system , fibrosis , pharmacology , microbiology and biotechnology , antibiotics , anesthesia , biology , biochemistry

Azithromycin (AZM) has shown promising anti-inflammatory properties in chronic obstructive pulmonary diseases, and clinical studies have presented an improvement in the respiratory condition of cystic fibrosis (CF) patients. The aim of this study was to investigate, in human airway cells, the mechanism by which AZM has beneficial effects in CF. We demonstrated that AZM did not have any anti-inflammatory effect on CF airway cells but restored Cl(-) efflux.

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