In Vitro Activity of Telavancin against Resistant Gram-Positive Bacteria | Zendy

Kevin M. Krause | Zendy; Marika Renelli | Zendy; Stacey Difuntorum | Zendy; Terry X. Wu | Zendy; Dmitri Debabov | Zendy; Bret M. Benton | Zendy

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In Vitro Activity of Telavancin against Resistant Gram-Positive Bacteria

Author(s) -

Kevin M. Krause,

Marika Renelli,

Stacey Difuntorum,

Terry X. Wu,

Dmitri Debabov,

Bret M. Benton

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01398-07

Subject(s) - microbiology and biotechnology , antimicrobial , in vitro , bacteria , gram positive bacteria , biology , chemistry , biochemistry , genetics

The in vitro activity of telavancin was tested against 743 predominantly antimicrobial-resistant, gram-positive isolates. Telavancin was highly active against methicillin-resistant staphylococci (MIC(90), 0.5 to 1 microg/ml), streptococci (all MICs, < or =0.12 microg/ml), and VanB-type enterococci (all MICs, < or =2 microg/ml). Time-kill studies demonstrated the potent bactericidal activity of telavancin.

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