Disparate Candida albicans Biofilm Formation in Clinical Lipid Emulsions Due to Capric Acid-Mediated Inhibition
Author(s) -
Hubertine M. E. Willems,
Jeremy S. Stultz,
Molly E. Coltrane,
Jabez P. Fortwendel,
Brian M. Peters
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01394-19
Subject(s) - biofilm , candida albicans , corpus albicans , capric acid , microbiology and biotechnology , chemistry , biology , biochemistry , bacteria , fatty acid , genetics , lauric acid
Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungusCandida albicans , which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN solutions contain lipid emulsions to supply daily essential fats and are often delivered via central venous catheters (CVCs).
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