Novel Plasmid-Borne Multidrug Resistance Gene Cluster Including lsa (E) from a Linezolid-Resistant Enterococcus faecium Isolate of Swine Origin | Zendy

Hongbin Si | Zendy; Wanjiang Zhang | Zendy; Shengbo Chu | Zendy; Xiumei Wang | Zendy; Lei Dai | Zendy; Xin Hua | Zendy; Zhimin Dong | Zendy; Štefan Schwarz | Zendy; Siguo Liu | Zendy

Open Access

Novel Plasmid-Borne Multidrug Resistance Gene Cluster Including lsa (E) from a Linezolid-Resistant Enterococcus faecium Isolate of Swine Origin

Author(s) -

Hongbin Si,

Wanjiang Zhang,

Shengbo Chu,

Xiumei Wang,

Lei Dai,

Xin Hua,

Zhimin Dong,

Štefan Schwarz,

Siguo Liu

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01394-15

Subject(s) - plasmid , linezolid , kanamycin , biology , enterococcus faecium , lincosamides , enterococcus , microbiology and biotechnology , genetics , enterococcus faecalis , multiple drug resistance , gene , antibiotic resistance , drug resistance , antibiotics , staphylococcus aureus , vancomycin , escherichia coli , bacteria

A novel nonconjugative plasmid of 28,489 bp from a porcine linezolid-resistant Enterococcus faecium isolate was completely sequenced. This plasmid harbored a novel type of multiresistance gene cluster that comprised the resistance genes lnu(B), lsa(E), spw, aadE, aphA3, and two copies of erm(B), which account for resistance to macrolides, lincosamides, streptogramins, pleuromutilins, streptomycin, spectinomycin, and kanamycin/neomycin. Structural comparisons suggested that this plasmid might have developed from other enterococcal plasmids by insertion element (IS)-mediated interplasmid recombination processes.

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