Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort | Zendy

George R. Thompson | Zendy; Charles R. Krois | Zendy; Verena K. Affolter | Zendy; Angela Everett | Zendy; Eeva Varjonen | Zendy; Victoria R. Sharon | Zendy; Anil Singapuri | Zendy; Michael J. Dennis | Zendy; Ian McHardy | Zendy; Hong Sik Yoo | Zendy; Dawn M. Fedor | Zendy; Nathan P. Wiederhold | Zendy; Phylicia Aaron | Zendy; Angie Gelli | Zendy; Joseph L. Napoli | Zendy; Stephen D. White | Zendy

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Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort

Author(s) -

George R. Thompson,

Charles R. Krois,

Verena K. Affolter,

Angela Everett,

Eeva Varjonen,

Victoria R. Sharon,

Anil Singapuri,

Michael J. Dennis,

Ian McHardy,

Hong Sik Yoo,

Dawn M. Fedor,

Nathan P. Wiederhold,

Phylicia Aaron,

Angie Gelli,

Joseph L. Napoli,

Stephen D. White

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01384-18

Subject(s) - fluconazole , medicine , animal model , dermatology , pharmacology , antifungal

Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.

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