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Acinetobacter baumannii is an opportunistic pathogen that is an important source of nosocomial infections. Production of extended-spectrum β-lactamases (ESBLs) of the GES type inA. baumannii has been increasingly reported, and some of these GES-type enzymes possess some carbapenemase activity. Our aim was to analyze the resistance determinants and the clonal relationships of carbapenem-nonsusceptibleA. baumannii clinical isolates recovered from hospitals in Kuwait. A total of 63 isolates were analyzed, and all were found to be positive forbla GES -type genes. One isolate harbored thebla GES-14 gene encoding an ESBL with significant carbapenemase activity, whereas the other isolates harbored thebla GES-11 ESBL gene. Thirty-three isolates coharbored thebla OXA-23 andbla GES-11 genes. Analyses of the genetic locations indicated that thebla GES-11/-14 genes were plasmid located. It is noteworthy that thebla OXA-23 andbla GES-11 genes were colocated onto a single plasmid. Nine different pulsotypes were observed among the 63 isolates. This study showed the emergence of GES-type ESBLs inA. baumannii in Kuwait, further suggesting that the Middle East region might be a reservoir for carbapenemase-producingA. baumannii .

Wide Dissemination of GES-Type Carbapenemases in Acinetobacter baumannii Isolates in Kuwait