Wide Dissemination of GES-Type Carbapenemases in Acinetobacter baumannii Isolates in Kuwait | Zendy

Rémy A. Bonnin | Zendy; Vincent O. Rotimi | Zendy; Mona Al Hubail | Zendy; Elise Gasiorowski | Zendy; Noura Al Sweih | Zendy; Patrice Nordmann | Zendy; Laurent Poirel | Zendy

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Wide Dissemination of GES-Type Carbapenemases in Acinetobacter baumannii Isolates in Kuwait

Author(s) -

Rémy A. Bonnin,

Vincent O. Rotimi,

Mona Al Hubail,

Elise Gasiorowski,

Noura Al Sweih,

Patrice Nordmann,

Laurent Poirel

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01384-12

Subject(s) - acinetobacter baumannii , microbiology and biotechnology , acinetobacter , biology , antibiotics , bacteria , pseudomonas aeruginosa , genetics

Acinetobacter baumannii is an opportunistic pathogen that is an important source of nosocomial infections. Production of extended-spectrum β-lactamases (ESBLs) of the GES type inA. baumannii has been increasingly reported, and some of these GES-type enzymes possess some carbapenemase activity. Our aim was to analyze the resistance determinants and the clonal relationships of carbapenem-nonsusceptibleA. baumannii clinical isolates recovered from hospitals in Kuwait. A total of 63 isolates were analyzed, and all were found to be positive forbla GES -type genes. One isolate harbored thebla GES-14 gene encoding an ESBL with significant carbapenemase activity, whereas the other isolates harbored thebla GES-11 ESBL gene. Thirty-three isolates coharbored thebla OXA-23 andbla GES-11 genes. Analyses of the genetic locations indicated that thebla GES-11/-14 genes were plasmid located. It is noteworthy that thebla OXA-23 andbla GES-11 genes were colocated onto a single plasmid. Nine different pulsotypes were observed among the 63 isolates. This study showed the emergence of GES-type ESBLs inA. baumannii in Kuwait, further suggesting that the Middle East region might be a reservoir for carbapenemase-producingA. baumannii .

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