In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp | Zendy

A. Raffetin | Zendy; V. Courbin | Zendy; Vincent Jullien | Zendy; Éric Dannaoui | Zendy

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In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp

Author(s) -

A. Raffetin,

V. Courbin,

Vincent Jullien,

Éric Dannaoui

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01382-17

Subject(s) - caspofungin , anidulafungin , echinocandins , micafungin , antagonism , microbiology and biotechnology , azole , biology , aspergillus , agar , checkerboard , voriconazole , antifungal , bacteria , biochemistry , genetics , receptor

In vitro combinations of isavuconazole with echinocandins were evaluated against 30 Aspergillus strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains.

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