Open AccessMulticentric Analysis of the Species Distribution and Antifungal Susceptibility of Cryptic Isolates from Aspergillus Section Fumigati
Author(s) -
Sébastien Imbert,
AnneCécile Normand,
Sophie Cassaing,
Frédéric Gabriel,
Lise Kristensen,
Christine Bonnal,
Laurence Lachaud,
Damien Costa,
Juliette Guitard,
Lilia Hasseine,
M. Palous,
Martine Piarroux,
Marijke Hendrickx,
Renaud Piarroux,
Arnaud Fekkar
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01374-20
Subject(s) - aspergillus , biology , species complex , amphotericin b , microbiology and biotechnology , antifungal , azole , fungi imperfecti , aspergillosis , aspergillus niger , botany , genetics , gene , phylogenetic tree
The antifungal susceptibility of Aspergillus cryptic species is poorly known. We assessed 51 isolates, belonging to seven Fumigati cryptic species, by the EUCAST reference method and the concentration gradient strip (CGS) method. Species-specific patterns were observed, with high MICs for azole drugs, except for Aspergillus hiratsukae and Aspergillus tsurutae , and high MICs for amphotericin B for Aspergillus lentulus and Aspergillus udagawae Essential and categorical agreements between EUCAST and CGS results were between 53.3 and 93.3%.