Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis | Zendy

Hiroshi Kakeya | Zendy; Yoshitsugu Miyazaki | Zendy; Hisato Senda | Zendy; Tsutomu Kobayashi | Zendy; Masafumi Seki | Zendy; Koichi Izumikawa | Zendy; Kazunori Yanagihara | Zendy; Yoshihiro Yamamoto | Zendy; Takayoshi Tashiro | Zendy; Shigeru Kohno | Zendy

Open Access

Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis

Author(s) -

Hiroshi Kakeya,

Yoshitsugu Miyazaki,

Hisato Senda,

Tsutomu Kobayashi,

Masafumi Seki,

Koichi Izumikawa,

Kazunori Yanagihara,

Yoshihiro Yamamoto,

Takayoshi Tashiro,

Shigeru Kohno

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01369-07

Subject(s) - amphotericin b , micafungin , aspergillosis , polyene , aspergillus fumigatus , mycosis , antifungal , pharmacology , medicine , biology , surgery , immunology , dermatology , biochemistry

SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).

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