Pyrazinoic Acid and Its n -Propyl Ester Inhibit Fatty Acid Synthase Type I in Replicating Tubercle Bacilli | Zendy

Oren Zimhony | Zendy; Catherine Vilchèze | Zendy; Masayoshi Arai | Zendy; John T. Welch | Zendy; William R. Jacobs | Zendy

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Pyrazinoic Acid and Its n -Propyl Ester Inhibit Fatty Acid Synthase Type I in Replicating Tubercle Bacilli

Author(s) -

Oren Zimhony,

Catherine Vilchèze,

Masayoshi Arai,

John T. Welch,

William R. Jacobs

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01369-06

Subject(s) - pyrazinamide , bacilli , antimycobacterial , mycobacterium tuberculosis , tubercle , microbiology and biotechnology , biochemistry , palmitic acid , biology , chemistry , fatty acid , bacteria , tuberculosis , antibiotics , medicine , genetics , rifampicin , pathology

The activity of different analogs of pyrazinamide on Mycobacterium tuberculosis fatty acid synthase type I (FASI) in replicating bacilli was studied. Palmitic acid biosynthesis was diminished by 96% in bacilli treated with n-propyl pyrazinoate, 94% in bacilli treated with 5-chloro-pyrazinamide, and 97% in bacilli treated with pyrazinoic acid, the pharmacologically active agent of pyrazinamide. We conclude that the minimal structure of pyrazine ring with an acyl group is sufficient for FASI inhibition and antimycobacterial activity.

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