A Single Nucleotide Change in the Promoter mutp Enhances Fluoride Resistance of Streptococcus mutans | Zendy

Ying Liao | Zendy; Bernd W. Brandt | Zendy; Min Zhang | Zendy; Jiyao Li | Zendy; Wim Crielaard | Zendy; C. van Loveren | Zendy; Dongmei Deng | Zendy

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A Single Nucleotide Change in the Promoter mutp Enhances Fluoride Resistance of Streptococcus mutans

Author(s) -

Ying Liao,

Bernd W. Brandt,

Min Zhang,

Jiyao Li,

Wim Crielaard,

C. van Loveren,

Dongmei Deng

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01366-16

Subject(s) - fluoride , streptococcus mutans , mutation , gene , nucleotide , microbiology and biotechnology , biology , antiporter , genetics , chemistry , bacteria , membrane , inorganic chemistry

Previously, we identified a single nucleotide mutation in the promoter (mutp) of the fluoride antiporter-coding genes in a naturally fluoride-resistant Streptococcus mutans strain. Here, we studied the role of this mutation in a defined genetic background. The results confirmed that this mutation alone confers fluoride resistance on S. mutans, as shown by growth and lactic acid production assays. This resistance was explained by constitutively higher mutp promoter activity and upregulation of the fluoride antiporter-coding genes.

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