Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni , Fasciola hepatica , Clonorchis sinensis , and Opisthorchis viverrini | Zendy

Jennifer Keiser | Zendy; Shu-Hua Xiao | Zendy; Jacques Chollet | Zendy; Marcel Tanner | Zendy; Jürg Utzinger | Zendy

Open Access

Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni , Fasciola hepatica , Clonorchis sinensis , and Opisthorchis viverrini

Author(s) -

Jennifer Keiser,

Shu-Hua Xiao,

Jacques Chollet,

Marcel Tanner,

Jürg Utzinger

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01366-06

Subject(s) - opisthorchis viverrini , clonorchis sinensis , fasciola hepatica , schistosoma mansoni , opisthorchiasis , opisthorchis , biology , hepatica , praziquantel , liver fluke , clonorchiasis , helminthiasis , helminths , schistosomiasis , immunology , medicine

We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research