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We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.

antimicrobial agents and chemotherapy

Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni , Fasciola hepatica , Clonorchis sinensis , and Opisthorchis viverrini