Open AccessEmergence of Raoultella ornithinolytica Coproducing IMP-4 and KPC-2 Carbapenemases in China
Author(s) -
Beiwen Zheng,
Jing Zhang,
Jinru Ji,
Yunhui Fang,
Ping Shen,
Chaoqun Ying,
Jifang Lv,
Yonghong Xiao,
Lanjuan Li
Publication year - 2015
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01363-15
Subject(s) - biology , klebsiella pneumoniae , microbiology and biotechnology , plasmid , virology , gene , genetics , escherichia coli
We report here the emergence of seven IMP-4-producingRaoultella ornithinolytica isolates obtained from one patient. All isolates carried thebla IMP-4 carbapenemase gene, five isolates also carriedbla SHV-12 , four containedbla TEM-1 , and one containedbla OXA-1 . Notably, theR. ornithinolytica isolate Ro25724 also expressedKlebsiella pneumoniae carbapenemase (KPC)-2. Thebla KPC-2 gene was located on a Tn3 -Tn4401 integration structure on a plasmid of ∼450 kb. This is the first description of the coexistence ofbla KPC-2 andbla IMP-4 from the genusRaoultella .
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