Synthetic Ingenols Maximize Protein Kinase C-Induced HIV-1 Latency Reversal | Zendy

Adam M. Spivak | Zendy; Racheal A. Nell | Zendy; Mark E. Petersen | Zendy; Laura Martins | Zendy; Paul R. Sebahar | Zendy; Ryan Looper | Zendy; Vicente Planelles | Zendy

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Synthetic Ingenols Maximize Protein Kinase C-Induced HIV-1 Latency Reversal

Author(s) -

Adam M. Spivak,

Racheal A. Nell,

Mark E. Petersen,

Laura Martins,

Paul R. Sebahar,

Ryan Looper,

Vicente Planelles

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01361-18

Subject(s) - latency (audio) , human immunodeficiency virus (hiv) , cytotoxicity , protein kinase c , virus latency , chemistry , immune system , kinase , pharmacology , viral replication , biology , immunology , biochemistry , in vitro , virus , computer science , telecommunications

Antiretroviral therapy (ART) does not cure HIV-1 infection due to the persistence of proviruses in long-lived resting T cells. Strategies targeting these latently infected cells will be necessary to eradicate HIV-1 in infected individuals.

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