Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections | Zendy

Sheryl Zelenitsky | Zendy; Divna Calic | Zendy; Rakesh C. Arora | Zendy; Hilary P. Grocott | Zendy; Ted M. Lakowski | Zendy; L. Ryan | Zendy; Robert E. Ariano | Zendy

Open Access

Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections

Author(s) -

Sheryl Zelenitsky,

Divna Calic,

Rakesh C. Arora,

Hilary P. Grocott,

Ted M. Lakowski,

L. Ryan,

Robert E. Ariano

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01360-18

Subject(s) - cefazolin , medicine , cardiac surgery , antimicrobial , surgery , anesthesia , antibiotics , biology , microbiology and biotechnology

This study characterizes the pharmacodynamics of antimicrobial prophylaxis and sternal wound infections following cardiac surgery. Duration of surgery and cefazolin plasma concentration during wound closure were independently associated with surgical site infection at 30 days.

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