Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of Olorofim (F901318), a Novel Antifungal Drug, in Human Plasma and Serum | Zendy

Carsten Müller | Zendy; Cornelia Fietz | Zendy; Philipp Koehler | Zendy; Graham E. M. Sibley | Zendy; Nforbugwe Achu Che Awah | Zendy; Thomas Streichert | Zendy; Martin H. J. Wiesen | Zendy

Open Access

Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of Olorofim (F901318), a Novel Antifungal Drug, in Human Plasma and Serum

Author(s) -

Carsten Müller,

Cornelia Fietz,

Philipp Koehler,

Graham E. M. Sibley,

Nforbugwe Achu Che Awah,

Thomas Streichert,

Martin H. J. Wiesen

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01356-18

Subject(s) - chromatography , antifungal , tandem mass spectrometry , liquid chromatography–mass spectrometry , mass spectrometry , chemistry , drug , antifungal drug , tandem , human plasma , pharmacology , medicine , biology , microbiology and biotechnology , materials science , composite material

A fast and easy-to-use liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination and quantification of a novel antifungal drug, olorofim (F901318), a member of the novel class of orotomides, in human plasma and serum was developed and validated. Sample preparation was based on protein precipitation with acetonitrile and subsequent centrifugation.

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