Activity of Imipenem against Klebsiella pneumoniae Biofilms In Vitro and In Vivo | Zendy

Ping Chen | Zendy; Akhil K. Seth | Zendy; Johnathan J. Abercrombie | Zendy; Thomas A. Mustoe | Zendy; Kai P. Leung | Zendy

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Activity of Imipenem against Klebsiella pneumoniae Biofilms In Vitro and In Vivo

Author(s) -

Ping Chen,

Akhil K. Seth,

Johnathan J. Abercrombie,

Thomas A. Mustoe,

Kai P. Leung

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01353-13

Subject(s) - klebsiella pneumoniae , imipenem , microbiology and biotechnology , in vivo , in vitro , biofilm , klebsiella , antibiotics , biology , chemistry , bacteria , escherichia coli , antibiotic resistance , biochemistry , genetics , gene

Encapsulated Klebsiella pneumoniae has emerged as one of the most clinically relevant and more frequently encountered opportunistic pathogens in combat wounds as the result of nosocomial infection. In this report, we show that imipenem displayed potent activity against established K. pneumoniae biofilms under both static and flow conditions in vitro. Using a rabbit ear model, we also demonstrated that imipenem was highly effective against preformed K. pneumoniae biofilms in wounds.

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