Characterization of Cefoxitin-Resistant Escherichia coli Isolates from Recreational Beaches and Private Drinking Water in Canada between 2004 and 2006 | Zendy

Laura Mataseje | Zendy; Norman F. Neumann | Zendy; B. Crago | Zendy; Patricia J. Baudry | Zendy; George G. Zhanel | Zendy; Marie Louie | Zendy; M. R. Mulvey | Zendy

Open Access

Characterization of Cefoxitin-Resistant Escherichia coli Isolates from Recreational Beaches and Private Drinking Water in Canada between 2004 and 2006

Author(s) -

Laura Mataseje,

Norman F. Neumann,

B. Crago,

Patricia J. Baudry,

George G. Zhanel,

Marie Louie,

M. R. Mulvey

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01353-08

Subject(s) - cefoxitin , escherichia coli , microbiology and biotechnology , plasmid , biology , multiple drug resistance , replicon , phylogenetic tree , enterobacteriaceae , gene , bacteria , drug resistance , genetics , staphylococcus aureus

A total of 142 cefoxitin-resistantEscherichia coli isolates from water sources were collected across Canada. Multidrug resistance was observed in 65/142 (45.8%) isolates. Thebla CMY-2 gene was identified in 110/142 (77.5%) isolates. Sequencing of the chromosomalampC promoter region showed mutations from the wild type, previously shown to hyperproduce AmpC. CMY-2-producing plasmids predominantly belonged to replicon groups I1-Iγ, A/C, and K/B. The majority of theE. coli isolates belonged to the nonvirulent phylogenetic groups A and B1.

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