Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast | Zendy

Nitesh Khandelwal | Zendy; Mohd Wasi | Zendy; Remya Nair | Zendy; Meghna Gupta | Zendy; Mohit Kumar | Zendy; Alok K. Mondal | Zendy; Naseem A. Gaur | Zendy; Rajendra Prasad | Zendy

Open Access

Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast

Author(s) -

Nitesh Khandelwal,

Mohd Wasi,

Remya Nair,

Meghna Gupta,

Mohit Kumar,

Alok K. Mondal,

Naseem A. Gaur,

Rajendra Prasad

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01347-18

Subject(s) - azole , atp binding cassette transporter , biology , candida albicans , biochemistry , saccharomyces cerevisiae , efflux , mutant , multiple drug resistance , permease , yeast , microbiology and biotechnology , drug resistance , transporter , gene , antifungal

Target alteration and overproduction and drug efflux through overexpression of multidrug transporters localized in the plasma membrane represent the conventional mechanisms of azole antifungal resistance. Here, we identify a novel conserved mechanism of azole resistance not only in the budding yeastSaccharomyces cerevisiae but also in the pathogenic yeastCandida albicans .

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