A Peptide with a ProGln C Terminus in the Human Saliva Peptidome Exerts Bactericidal Activity against Propionibacterium acnes | Zendy

ChunMing Huang | Zendy; Justin W. Torpey | Zendy; Yu-Tseung Liu | Zendy; YunRu Chen | Zendy; Katherine Williams | Zendy; Elizabeth A. Komives | Zendy; Richard L. Gallo | Zendy

Open Access

A Peptide with a ProGln C Terminus in the Human Saliva Peptidome Exerts Bactericidal Activity against Propionibacterium acnes

Author(s) -

ChunMing Huang,

Justin W. Torpey,

Yu-Tseung Liu,

YunRu Chen,

Katherine Williams,

Elizabeth A. Komives,

Richard L. Gallo

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01347-07

Subject(s) - propionibacterium acnes , peptide , chemistry , microbiology and biotechnology , innate immune system , glutamine , saliva , tandem mass spectrometry , biochemistry , bacteria , amino acid , mass spectrometry , biology , chromatography , genetics , receptor

Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positivePropionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of variousP. acnes -associated human diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research