Open AccessA Peptide with a ProGln C Terminus in the Human Saliva Peptidome Exerts Bactericidal Activity against Propionibacterium acnes
Author(s) -
Chun Ming Huang,
Justin W. Torpey,
Yu Tseung Liu,
YunRu Chen,
Katherine E. Williams,
Elizabeth A. Komives,
Richard L. Gallo
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01347-07
Subject(s) - propionibacterium acnes , peptide , chemistry , microbiology and biotechnology , innate immune system , glutamine , saliva , tandem mass spectrometry , biochemistry , bacteria , amino acid , mass spectrometry , biology , chromatography , genetics , receptor
Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positivePropionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of variousP. acnes -associated human diseases.