In Vitro Activity of the Oxazolidinone RWJ-416457 against Linezolid-Resistant and -Susceptible Staphylococci and Enterococci | Zendy

David M. Livermore | Zendy; Marina Warner | Zendy; Shazad Mushtaq | Zendy; Sarah North | Zendy; Neil Woodford | Zendy

Open Access

In Vitro Activity of the Oxazolidinone RWJ-416457 against Linezolid-Resistant and -Susceptible Staphylococci and Enterococci

Author(s) -

David M. Livermore,

Marina Warner,

Shazad Mushtaq,

Sarah North,

Neil Woodford

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01347-06

Subject(s) - linezolid , 23s ribosomal rna , microbiology and biotechnology , staphylococcus aureus , biology , enterococcus faecalis , antibacterial agent , enterococcus , in vitro , antibiotics , bacteria , gene , genetics , vancomycin , rna , ribosome

RWJ-416457, a novel oxazolidinone, had modal MICs of 0.5 to 1 microg/ml for linezolid-susceptible staphylococci and enterococci, versus linezolid MICs for these organisms of 1 or 2 microg/ml. RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 microg/ml, versus linezolid MICs of 8 to 64 microg/ml; actual values reflected the proportion of gene copies mutated.

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