Plasma Concentrations of Isoniazid and Rifampin Are Decreased in Adult Pulmonary Tuberculosis Patients with Diabetes Mellitus | Zendy

Aylin Babalık | Zendy; İsmail H. Ulus | Zendy; Nadi Bakırcı | Zendy; Tülin Kuyucu | Zendy; Hüseyin Arpağ | Zendy; Lale Dağyildizi | Zendy; Esen Capaner | Zendy

Open Access

Plasma Concentrations of Isoniazid and Rifampin Are Decreased in Adult Pulmonary Tuberculosis Patients with Diabetes Mellitus

Author(s) -

Aylin Babalık,

İsmail H. Ulus,

Nadi Bakırcı,

Tülin Kuyucu,

Hüseyin Arpağ,

Lale Dağyildizi,

Esen Capaner

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01345-13

Subject(s) - pyrazinamide , ethambutol , isoniazid , medicine , tuberculosis , diabetes mellitus , gastroenterology , rifampicin , pharmacology , pulmonary tuberculosis , endocrinology , pathology

Plasma isoniazid and rifampin concentrations, but not pyrazinamide and ethambutol concentrations, were decreased by about 50% (P < 0.05) in diabetic pulmonary tuberculosis patients. The prevalences of subnormal plasma isoniazid, rifampin, pyrazinamide, and ethambutol concentrations were 49% or 100% (P < 0.01), 66% or 100% (P < 0.05), 30% or 50% (P = 0.198), and 32% or 21% (P = 0.742) in nondiabetic or diabetic tuberculosis patients, respectively. These data show that plasma concentrations of isoniazid and rifampin were greatly reduced in diabetic tuberculosis patients.

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