Antibiotic Resistance and Substrate Profiles of the Class A Carbapenemase KPC-6 | Zendy

Toni L. Lamoureaux | Zendy; Hilary Frase | Zendy; Nuno T. Antunes | Zendy; Sergei B. Vakulenko | Zendy

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Antibiotic Resistance and Substrate Profiles of the Class A Carbapenemase KPC-6

Author(s) -

Toni L. Lamoureaux,

Hilary Frase,

Nuno T. Antunes,

Sergei B. Vakulenko

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01338-12

Subject(s) - antibiotics , microbiology and biotechnology , antibiotic resistance , biology

The class A carbapenemase KPC-6 produces resistance to a broad range of β-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M(-1) s(-1). The catalytic efficiencies of KPC-6 against cephems vary to a greater extent, ranging from 10(3) M(-1) s(-1) for the cephamycin cefoxitin and the extended-spectrum cephalosporin ceftazidime to 10(5) to 10(6) M(-1) s(-1) for the narrow-spectrum and some of the extended-spectrum cephalosporins.

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