Open AccessLoss of C-5 Sterol Desaturase Activity in Candida albicans : Azole Resistance or Merely Trailing Growth?
Author(s) -
Arturo Luna-Tapia,
Arielle Butts,
Glen E. Palmer
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01337-18
Subject(s) - azole , candida albicans , sterol , efflux , biology , microbiology and biotechnology , drug resistance , enzyme , in vitro , cholesterol , antifungal , biochemistry
Increased expression of drug efflux pumps and changes in the target enzyme Erg11p are known to contribute to azole resistance inCandida albicans , one of the most prevalent fungal pathogens. Mutations that inactivateERG3 , which encodes sterol Δ5,6 -desaturase, also conferin vitro azole resistance.
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