Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection | Zendy

Kageto Yamada | Zendy; Ryoichi Saito | Zendy; Saori Muto | Zendy; Machiko Kashiwa | Zendy; Yoshiko Tamamori | Zendy; Shingo Fujisaki | Zendy

Open Access

Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection

Author(s) -

Kageto Yamada,

Ryoichi Saito,

Saori Muto,

Machiko Kashiwa,

Yoshiko Tamamori,

Shingo Fujisaki

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01336-17

Subject(s) - moraxella catarrhalis , moraxella (branhamella) catarrhalis , microbiology and biotechnology , levofloxacin , biology , moraxella , ofloxacin , antibacterial agent , in vitro , bacteria , ciprofloxacin , antibiotics , genetics , haemophilus influenzae

Moraxella catarrhalis causes respiratory infections. In this study, fluoroquinolone-resistant strains were selectedin vitro to evaluate the mechanism of fluoroquinolone resistance. Strains with reduced fluoroquinolone susceptibility were obtained by stepwise selection in levofloxacin, and fluoroquinolone targetsgyr andpar were sequenced. Six novel mutations in GyrA (D84Y, T594dup, and A722dup), GyrB (E479K and D439N), and ParE (Q395R) involved inM. catarrhalis resistance to fluoroquinolones were revealed.

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