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A novel, plasmid-mediated, high-level tigecycline resistancetet (X) gene variant,tet (X5), was detected in a clinicalAcinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. Thetet (X5)-containing plasmid could only be transferred toA. baumannii via electrotransformation.

antimicrobial agents and chemotherapy

Novel Plasmid-Mediated <i>tet</i> (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

Novel Plasmid-Mediated tet (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate