Novel Plasmid-Mediated tet (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate | Zendy

Liyuan Wang | Zendy; Dejun Liu | Zendy; Yuan Lv | Zendy; Lanqing Cui | Zendy; Yun Li | Zendy; Tianmeng Li | Zendy; Huangwei Song | Zendy; Yuxin Hao | Zendy; Jianzhong Shen | Zendy; Yang Wang | Zendy; Timothy R. Walsh | Zendy

Open Access

Novel Plasmid-Mediated tet (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

Author(s) -

Liyuan Wang,

Dejun Liu,

Yuan Lv,

Lanqing Cui,

Yun Li,

Tianmeng Li,

Huangwei Song,

Yuxin Hao,

Jianzhong Shen,

Yang Wang,

Timothy R. Walsh

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01326-19

Subject(s) - tigecycline , acinetobacter baumannii , plasmid , microbiology and biotechnology , biology , gene , bacteria , antibiotics , genetics , pseudomonas aeruginosa

A novel, plasmid-mediated, high-level tigecycline resistancetet (X) gene variant,tet (X5), was detected in a clinicalAcinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. Thetet (X5)-containing plasmid could only be transferred toA. baumannii via electrotransformation.

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