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Two cases of pulmonary infection due to strains of multidrug-resistant Klebsiella pneumoniae were investigated. Beta-lactamase determinants, such as bla(IMP-4) and bla(SHV-12), and the 16S rRNA methyltransferase-encoding gene armA were detected in these plasmid-bearing organisms. The integron-borne bla(IMP-4) and armA contained intervening sequences highly related to those of a Vibrio cholerae O139 plasmid found in Hangzhou, China.

antimicrobial agents and chemotherapy

Two Clinical Strains of Klebsiella pneumoniae Carrying Plasmid-Borne bla IMP-4 , bla SHV-12 , and armA Isolated at a Pediatric Center in Shanghai, China