Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla IMP-1 in a Tertiary Hospital | Zendy

Ana Carolina Ramos | Zendy; Rodrigo Cayô | Zendy; Cecília G Carvalhaes | Zendy; Thomas Jové | Zendy; Greice Pereira da Silva | Zendy; Fernanda Maciel Paschoin Sancho | Zendy; Thomas C. Chagas-Neto | Zendy; Eduardo Alexandrino Medeiros | Zendy; Ana Cristina Gales | Zendy

Open Access

Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla _IMP-1 in a Tertiary Hospital

Author(s) -

Ana Carolina Ramos,

Rodrigo Cayô,

Cecília G Carvalhaes,

Thomas Jové,

Greice Pereira da Silva,

Fernanda Maciel Paschoin Sancho,

Thomas C. Chagas-Neto,

Eduardo Alexandrino Medeiros,

Ana Cristina Gales

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01321-17

Subject(s) - integron , proteus mirabilis , tigecycline , multiple drug resistance , microbiology and biotechnology , biology , polymyxin , plasmid , enterobacteriaceae , proteus , klebsiella pneumoniae , antibiotics , antibiotic resistance , genetics , gene , escherichia coli

This study aimed to characterize multidrug-resistantProteus mirabilis clones carrying a novel class 1 integron-bornebla IMP-1 . In1359 was inserted into a large conjugative plasmid that also carriedbla CTX-M-2 . The production of carbapenemases inEnterobacteriaceae that are intrinsically resistant to polymyxins and tigecycline is very worrisome, representing a serious challenge to clinicians and infection control teams.

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