In Vitro Activity of PBTZ169 against Multiple Mycobacterium Species | Zendy

Jin Shi | Zendy; Jie Lu | Zendy; Shu’an Wen | Zendy; Zhaojing Zong | Zendy; Fengmin Huo | Zendy; Jingjing Luo | Zendy; Qian Liang | Zendy; Yunxu Li | Zendy; Hairong Huang | Zendy; Yu Pang | Zendy

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In Vitro Activity of PBTZ169 against Multiple Mycobacterium Species

Author(s) -

Jin Shi,

Jie Lu,

Shu’an Wen,

Zhaojing Zong,

Fengmin Huo,

Jingjing Luo,

Qian Liang,

Yunxu Li,

Hairong Huang,

Yu Pang

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01314-18

Subject(s) - mycobacterium fortuitum , in vitro , mycobacterium , biology , microbiology and biotechnology , genotype , amino acid , mutant , oxidase test , gene , genetics , bacteria , biochemistry , enzyme

In this study, we demonstrate that PBTZ169 exhibits significant differences inin vitro activity against multipleMycobacterium species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d -ribose oxidase (DprE1) can be used as a surrogate marker forin vitro susceptibility to PBTZ169 in mycobacteria.

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