Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay | Zendy

Xiafei Wei | Zendy; Chun-Yang Gan | Zendy; Jing Cui | Zendy; Yingying Luo | Zendy; Xue-Fei Cai | Zendy; Yuan Yi | Zendy; Jing Shen | Zendy; Zhiying Li | Zendy; Wenlu Zhang | Zendy; Quanxin Long | Zendy; Yuan Hu | Zendy; Juan Chen | Zendy; Ni Tang | Zendy; Haitao Guo | Zendy; Ailong Huang | Zendy; Jieli Hu | Zendy

Open Access

Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay

Author(s) -

Xiafei Wei,

Chun-Yang Gan,

Jing Cui,

Yingying Luo,

Xue-Fei Cai,

Yuan Yi,

Jing Shen,

Zhiying Li,

Wenlu Zhang,

Quanxin Long,

Yuan Hu,

Juan Chen,

Ni Tang,

Haitao Guo,

Ailong Huang,

Jieli Hu

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01302-18

Subject(s) - luciferase , complementation , virology , protein fragment complementation assay , hepatitis b virus , identification (biology) , biology , virus , chemistry , microbiology and biotechnology , computational biology , biochemistry , transfection , gene , phenotype , botany

The capsid of the hepatitis B virus is an attractive antiviral target for developing therapies against chronic hepatitis B infection. Currently available core protein allosteric modulators (CpAMs) mainly affect one of the two major types of protein-protein interactions involved in the process of capsid assembly, namely, the interaction between the core dimers.

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