Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1 | Zendy

Kathryn J. Vollmer | Zendy; Anna C. Burns | Zendy; Hannah E. Sauer | Zendy; John D. Williams | Zendy; Gloria Komazin-Meredith | Zendy; Steve Cardinale | Zendy; Michelle M. Butler | Zendy; Zachary D. Aron | Zendy; Islam T. M. Hussein | Zendy; Marc Busch | Zendy; Terry L. Bowlin | Zendy; Brian G. Gentry | Zendy

Open Access

Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1

Author(s) -

Kathryn J. Vollmer,

Anna C. Burns,

Hannah E. Sauer,

John D. Williams,

Gloria Komazin-Meredith,

Steve Cardinale,

Michelle M. Butler,

Zachary D. Aron,

Islam T. M. Hussein,

Marc Busch,

Terry L. Bowlin,

Brian G. Gentry

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01301-19

Subject(s) - methylenecyclopropane , adenosine deaminase , nucleoside , enzyme , chemistry , mechanism of action , biochemistry , herpes simplex virus , dna , stereochemistry , virology , biology , virus , in vitro , catalysis

To determine the mechanism of action of third-generation methylenecyclopropane nucleoside analogs (MCPNAs), DNA sequencing of herpes simplex virus 1 (HSV-1) isolates resistant to third-generation MCPNAs resulted in the discovery of G841S and N815S mutations in HSV-1 UL30.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research