Changes in aac(6 ′ )-Ib-cr Prevalence and Fluoroquinolone Resistance in Nosocomial Isolates of Escherichia coli Collected from 1991 through 2005 | Zendy

Gabriela Warburg | Zendy; Maya Korem | Zendy; Ari Robicsek | Zendy; Dalia Engelstein | Zendy; Allon E. Moses | Zendy; Colin Block | Zendy; Jacob Strahilevitz | Zendy

Open Access

Changes in aac(6 ′ )-Ib-cr Prevalence and Fluoroquinolone Resistance in Nosocomial Isolates of Escherichia coli Collected from 1991 through 2005

Author(s) -

Gabriela Warburg,

Maya Korem,

Ari Robicsek,

Dalia Engelstein,

Allon E. Moses,

Colin Block,

Jacob Strahilevitz

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01300-08

Subject(s) - escherichia coli , ciprofloxacin , microbiology and biotechnology , enterobacteriaceae , tertiary care , biology , antibacterial agent , medicine , virology , antibiotics , gene , genetics

Clinical isolates ofEscherichia coli collected from 1991 through 2005 at a tertiary-care center were studied forqnr andaac(6 ′)-Ib-cr genes. Isolates bearingaac(6 ′)-Ib-cr emerged in 1998, coinciding with an increase in ciprofloxacin resistance. The presence ofaac(6 ′)-Ib-cr was multiclonal and was associated with the presence of extended-spectrum β-lactamases.

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