Open AccessChanges in aac(6 ′ )-Ib-cr Prevalence and Fluoroquinolone Resistance in Nosocomial Isolates of Escherichia coli Collected from 1991 through 2005
Author(s) -
Gabriela Warburg,
Maya Korem,
Ari Robicsek,
Dalia Engelstein,
Allon E. Moses,
C Block,
Jacob Strahilevitz
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01300-08
Subject(s) - escherichia coli , ciprofloxacin , microbiology and biotechnology , enterobacteriaceae , tertiary care , biology , antibacterial agent , medicine , virology , antibiotics , gene , genetics
Clinical isolates ofEscherichia coli collected from 1991 through 2005 at a tertiary-care center were studied forqnr andaac(6 ′)-Ib-cr genes. Isolates bearingaac(6 ′)-Ib-cr emerged in 1998, coinciding with an increase in ciprofloxacin resistance. The presence ofaac(6 ′)-Ib-cr was multiclonal and was associated with the presence of extended-spectrum β-lactamases.