Open AccessComplete Sequence of the IncT-Type Plasmid pT-OXA-181 Carrying the bla OXA-181 Carbapenemase Gene from Citrobacter freundii
Author(s) -
Laura Villa,
Alessandra Carattoli,
Patrice Nordmann,
Claudio Carta,
Laurent Poirel
Publication year - 2013
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01297-12
Subject(s) - citrobacter freundii , plasmid , klebsiella pneumoniae , gene , biology , citrobacter , sequence (biology) , insertion sequence , genetics , enterobacteriaceae , microbiology and biotechnology , escherichia coli , genome , transposable element
The gene encoding the carbapenemase OXA-181 (an OXA-48 variant) was identified from a Citrobacter freundii isolate coproducing NDM-1. The whole sequence of plasmid pT-OXA-181 bearing the blaOXA-181 gene was determined and revealed a 84-kb mobilizable but non-self-conjugative IncT-type plasmid. It totally differs from the 7.6-kb ColE-type and blaOXA-181-bearing plasmid recently identified in a Klebsiella pneumoniae isolate. However, in both plasmids, insertion sequence ISEcp1 might have played a role in acquisition of the blaOXA-181 gene.
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