In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance | Zendy

Sophie Zaloumis | Zendy; Pengxing Cao | Zendy; S Dini | Zendy; Miles P. Davenport | Zendy; Deborah Cromer | Zendy; David S. Khoury | Zendy; Freya J. I. Fowkes | Zendy; James M. McCaw | Zendy; J. A. Simpson | Zendy

Open Access

In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance

Author(s) -

Sophie Zaloumis,

Pengxing Cao,

S Dini,

Miles P. Davenport,

Deborah Cromer,

David S. Khoury,

Freya J. I. Fowkes,

James M. McCaw,

J. A. Simpson

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01292-18

Subject(s) - artemisinin , drug , drug resistance , pharmacology , in silico , medicine , combination therapy , malaria , artemisia annua , biology , plasmodium falciparum , immunology , microbiology and biotechnology , biochemistry , gene

Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug. With the emergence of resistance to the artemisinin derivatives and the potential pressure this exerts on the partner drugs, the impact of resistance to each drug on efficacy needs to be investigated.

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